MICRODISPERSE FORM OF IMMOBILIZED HEMOGLOBIN MODELING THE ERYTHROCYTES

Disperse systems based on hemoglobin sorption immobilization in reticu lar carboxylic polyelectrolytes are proposed as model of erythrocytes. The efficiency of oxygen transport of these systems is much higher th an that of native hemoglobin and is comparable with the gas transport of erythrocytes. This is believed to be due to highly selective sorpti on of hemoglobin in microdisperse forms of permeable polyelectrolytes. Microparticles of immobilized hemoglobin exhibit high local concentra tion of hemoglobin: the protein mass being one order of magnitude than that of polymer-carrier. Besides,it is presumed that structure of the carboxylic polyelectrolyte matrix is a polymer analog of 2,3-diphosph oglycerate. Microdispersion of immobilized hemoglobin exhibits a aggre gative resistance and have identity of surface charge with erythrocyte s. Studies in vivo have revealed biocompatibility of immobilized hemog lobin.