Controlled limb reperfusion was performed in two patients who were adm
itted for lower limb-threatening ischemia as a result of embolism. Aft
er embolectomy, the inflow blood was drained with a cannula and mixed
with a crystalloid solution to obtain an hyperosmolar, hypocalcemic, a
lkalotic, and substrate-enriched (aspartate, glutamate) reperfusate. T
his reperfusate was reinjected with a roller pump for 30 minutes throu
gh two cannulas inserted in the profunda and superficial femoral arter
ies. Temperature, intraarterial pressures, and flow were closely contr
olled. No complications occurred, and complete recovery of motor and s
ensory functions were observed, with restoration of pedal pulses.