M. Moroni et al., AMIFOSTINE (WR-2721, ETHYOL(TM)) CAN PROTECT HUMAN ENDOTHELIAL BUT NOT TUMOR-CELLS FROM CISPLATIN-INDUCED CYTOTOXICITY - AN IN-VITRO STUDY, Oncology Reports, 4(4), 1997, pp. 729-732
Amifostine (WR-2721, Ethyol(TM)) is a chemo-and radioprotective agent
which is increasingly used in clinical practice to minimize antitumor
therapy-induced toxicities. The key of this property of amifostine is
certainly its selective action in terms of differential protection of
normal tissue and not of tumor cells. Using HUVEC cells and three diff
erent cancer cell lines (A549 non-small cell lung cancer, DND-1A melan
oma and HeLa cervical carcinoma) we provide evidence that amifostine c
ould protect normal, and not cancer cells, from cisplatin (CDDP)-induc
ed cytotoxicity in vitro. Furthermore, low doses of amifostine, easily
attainable in vivo, can protect 50% of normal cells in vitro from CDD
P-induced cytotoxicity.