PRADIMICIN, A MANNOSE-BINDING ANTIBIOTIC, INDUCED CARBOHYDRATE-MEDIATED APOPTOSIS IN U937 CELLS

Authors
OKI T YAMAZAKI Y FURUMAI T IGARASHI Y
Citation
T. Oki et al., PRADIMICIN, A MANNOSE-BINDING ANTIBIOTIC, INDUCED CARBOHYDRATE-MEDIATED APOPTOSIS IN U937 CELLS, Bioscience, biotechnology, and biochemistry, 61(8), 1997, pp. 1408-1410
Citations number
15
Categorie Soggetti
Biology,Agriculture,"Biothechnology & Applied Migrobiology","Food Science & Tenology
Journal title
Bioscience, biotechnology, and biochemistry → ACNP
ISSN journal
09168451
Volume
61
Issue
8
Year of publication
1997
Pages
1408 - 1410
Database
ISI
SICI code
0916-8451(1997)61:8<1408:PAMAIC>2.0.ZU;2-L
Abstract
Pradimicin (PRM), a mannose-binding antifungal antibiotic, recognizes a D-mannoside in the presence of calcium. We demonstrated that BMY-288 64, a semi-synthetic analog of PRM, induced apoptosis in U937 cells wh ich had been incubated with 1-deosymannojirimycin (DMJ). Characteristi c morphological changes such as formation of apoptotic bodies and DNA fragmentation were observed in apoptotic cells.