Purpose: To demonstrate the signal characteristics of subcutaneous rhe
umatoid nodules in correlation to their histopathologic features. Meth
od: The magnetic resonance imaging (MRI) features of biopsy proven sub
cutaneous rheumatoid nodules are described in five patients with rheum
atoid arthritis established by classic criteria. Results: Two morpholo
gic appearances of rheumatoid nodules were observed on MRI: one predom
inantly cystic, with enhancing peripheral component; and a second type
which is predominantly solid, with uniform enhancement following gado
linium injection. Conclusion: Subcutaneous rheumatoid nodules can appe
ar by MR as solid, cystic, or a combination of both components. This c
losely correlates with their histopathologic evolution.