PULMONARY-EMBOLISM REVEALING UNDERLYING R ESISTANCE TO PROTEIN-C ACTIVATION

Resistance to the activation of protein C is a recently discovered con stitutional anomaly of coagulation which is responsible for thromboemb olic events ill young subjects. We report tr case in a 26 year old man who presented with pulmonary embolus. Laboratory data was characteris ed by an absence of any lengthening of the activated cephaline time af ter adding purified activated Exogenous Protein C. The confirmation of this anomaly is provided by the evidence of a mutation Arg 506 to Gln of Factor 5. The outcome is favourable with treatment by Heparin then by anti-Vitamin K.