SEPARATE MAGNOCELLULAR AND PARVOCELLULAR CONTRIBUTIONS FROM TEMPORAL ANALYSIS OF THE MULTIFOCAL VEP

Temporal analysis of the multifocal cortical visual evoked potential ( VEP) was studied using pseudo-random (m-sequence) achromatic stimulati on, The effects of variation of luminance contrast on the first-order response were complex, At low to mid contrasts (<60%), a wave doublet (P100-N115) predominated, A second wave complex (N100-P120-N160) domin ated at high contrasts, The second-order responses, however, showed an extremely simple variation with luminance contrast, Intrinsic differe nces in the adaptation time of the generators of these two components caused a distinct separation in the slices of the second-order respons e, A rapidly adapting nonlinearity saturating at low contrasts was onl y observable when measuring the responses from two consecutive flashes , Its latency coincided with the contrast saturating first-order respo nse component. By comparison, the nonlinearity derived from the respon ses to the stimuli with longer interstimulus intervals (second and thi rd slices) yielded a much more linear contrast response function with lower contrast gain and latencies, which clearly corresponded to the l onger latency component of the first-order response, Thus, the second- order responses show a first slice which is predominantly driven by ne ural elements that have a latency and contrast function that mimic tho se of the magnocellular neurons of the primate LGN and a second slice which is dominated by a generator whose properties resemble primate pa rvocellular function, This division into magno and parvocellular contr ibution to the VEP is based on function (interaction time) as distinct from other currently available analyses, with potential for neural an alysis of visual disease. (C) 1997 Elsevier Science Ltd.