It has been shown that properly designed Love-wave acoustic sensors ar
e very promising for sensing in gaseous and liquid environments becaus
e of their high sensitivity. Since Love-wave devices do not incur a ra
diative loss when used in a liquid, they have many potential applicati
ons in biosensing. We have successfully manufactured a range of 40 mu
m wavelength Love-wave devices based on SiO2/ST-quartz, with the SiO2
thickness ranging from 0 to 7.3 mu m. The relationship of the mass-loa
ding sensitivity to the thickness of the SiO2 layer has been obtained
experimentally. High sensitivity (greater than or equal to 300 cm(2) g
(-1)) is achieved at an SiO2 thickness between 3.5 and 6.5 mu m. The L
ove-wave oscillators have operated efficiently in various liquids with
excellent stability and low noise. In this paper, we report the exper
imental results for the devices operating in various liquids. The mass
sensitivity, insertion loss, oscillation frequency stability, noise l
evel, liquid viscous loading and acoustoelectric coupling have been st
udied. The influence of the thickness of the SiO2 layer an some of the
se properties has also been investigated.