SYNTHESIS OF WATER-SOLUBLE RUTHENIUM PORPHYRINS AS DNA CLEAVERS AND POTENTIAL CYTOTOXIC AGENTS

Authors
HARTMANN M ROBERT A DUARTE V KEPPLER BK MEUNIER B
Citation
M. Hartmann et al., SYNTHESIS OF WATER-SOLUBLE RUTHENIUM PORPHYRINS AS DNA CLEAVERS AND POTENTIAL CYTOTOXIC AGENTS, JBIC. Journal of biological inorganic chemistry, 2(4), 1997, pp. 427-432
Citations number
24
Categorie Soggetti
Biology,"Chemistry Inorganic & Nuclear
Journal title
JBIC. Journal of biological inorganic chemistry → ACNP
ISSN journal
09498257
Volume
2
Issue
4
Year of publication
1997
Pages
427 - 432
Database
ISI
SICI code
0949-8257(1997)2:4<427:SOWRPA>2.0.ZU;2-U
Abstract
Three new water-soluble ruthenium porphyrin complexes have been prepar ed and characterized, one with a cationic ligand, Ru(TMPyP), and two o thers with anionic ligands, Ru(p-COOH-PP) and Ru(TPPS). These differen t complexes and their manganese and iron analogues were tested in vivo as potential antitumor agents with mice bearing P388 leukemia cells, but these complexes have no significant antitumor activity. The nuclea se activity of Ru(TMPyP) and Ru(p-COOH-PP) was evaluated on supercoile d plasmid DNA after activation by a reducing agent (ascorbate) in the presence of air or by potassium monopersulfate. No significant activit y was evidenced for these ruthenium complexes, in contrast with the al ready known nuclease activity of the manganese and iron derivatives of TMPyP.