THE MIGRATION OF BONE-MARROW CELLS TO THYMIC CULTURE SUPERNATANTS IS INHIBITED BY STRESS

Authors
PEREZMERA ML FREIREGARABAL M ALVAREZMARTINEZ T REYMENDEZ M
Citation
Ml. Perezmera et al., THE MIGRATION OF BONE-MARROW CELLS TO THYMIC CULTURE SUPERNATANTS IS INHIBITED BY STRESS, Life sciences, 55(4), 1994, pp. 73-77
Citations number
21
Categorie Soggetti
Biology,"Medicine, Research & Experimental","Pharmacology & Pharmacy
Journal title
Life sciences → ACNP
ISSN journal
00243205
Volume
55
Issue
4
Year of publication
1994
Pages
73 - 77
Database
ISI
SICI code
0024-3205(1994)55:4<73:TMOBCT>2.0.ZU;2-C
Abstract
The effect of immobilization stress on precursor cell migration from b one marrow to the thymus was studied in C57BL/6 mice. The in vitro mig ration assays, using Nuclepore chambers, showed that precursor cell mi gration to thymus supernatants was strongly inhibited in stressed anim als. This inhibition of migration seemed to be cell-associated what ca n explain the thymic involution observed in mice under stress conditio ns. The migration of precursor cells from bone marrow may be one of th e mechanisms by which the thymus gland is involuted by stress.