SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF -[(ALPHA-METHYLBENZYLIDENE)-HYDRAZINO]BENZOXAZOLES

New 2-[(alpha-methylbenzylidene)hydrazino]benzoxazole derivatives have been synthesized by reacting ortho or para substituted acetophenones with 2-hydrazinobenzoxazole in ethanol. The structures of the synthesi zed compounds were confirmed by microanalysis, IR and NMR spectral dat a. Antimicrobial activities of the compounds were investigated by the microdilution susceptibility test in Mueller-Hinton broth and Sabourau d liquid medium. Test organisms: Staphylococcus aureus ATCC 29213 and Enterococcus faecalis ATCC 29212 as Gram (+) bacteria, Escherichia coi l ATCC 25922 and Pseudomonas aeruginosa ATCC 27853 as Gram (-) bacteri a, and Candida albicans, Candida stellatoidea, Candida parapsilosis an d Candida pseudotropicalis as yeasts. Among the compounds tested a-met hyl-4-chlorobenzylidene)hydrazino]benzoxazole (compound 4) and 2-[(alp ha-methyl-4-nitrobenzylidene)hydrazino] (compound 8) showed the most f avorable activity.