Rapid definitive hemorrhage control, both in the field and in the oper
ating room, remains an elusive goal in trauma patient management. Meth
ods to control hemorrhage have not changed for years. Dry Fibrin Seala
nt technology has progressed rapidly in the last several years, possib
ly allowing rapid definitive hemorrhage control. This article reviews
the history, theory, and problems with the homemade mixtures currently
in clinical use. Ln animal hemorrhage studies, Dry Fibrin Sealant pro
ducts have preserved blood pressure and significantly reduced blood lo
ss. Future applications of various delivery systems (dressing, foam, p
owder, liquid) also are discussed.