IN-VITRO STUDY OF THE ANTISEBORRHEIC ACTIVITY OF ZINC L-CYSTEATE - A NOVEL ZINC COMPOUND, ON RAT PREPUTIAL GLAND

Authors
GUILLARD O FAUCONNEAU B PIRIOU A PINEAU A
Citation
O. Guillard et al., IN-VITRO STUDY OF THE ANTISEBORRHEIC ACTIVITY OF ZINC L-CYSTEATE - A NOVEL ZINC COMPOUND, ON RAT PREPUTIAL GLAND, Pharmacology, 55(1), 1997, pp. 54-58
Citations number
34
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Pharmacology → ACNP
ISSN journal
00317012
Volume
55
Issue
1
Year of publication
1997
Pages
54 - 58
Database
ISI
SICI code
0031-7012(1997)55:1<54:ISOTAA>2.0.ZU;2-V
Abstract
The antiseborrheic effect of zinc L-cysteate, a new zinc compound, was evaluated in vitro by determining the lipidic metabolic activity of r at preputial glands as measured by incorporation of C-14-sodium acetat e. At 10(-3) and 10(-4) mol/l, zinc L-cysteate was more active than S- carboxymethyl L-cysteine used as reference in corresponding concentrat ions (p < 0.05 and p < 0.01, respectively). The pharmacologic results seem promising for clinical studies in dermatology.