A NEW POTENTIOMETRIC MEMBRANE SENSOR RESPONSIVE TO URIC-ACID

A new potentiometric membrane sensor responsive to uric acid has been developed. The membrane sensor is based on aliquat-urate, as an ion pa ir, and 2-NPOE as a plasticizer. The sensor exhibits fast, stable, and Nernstian response for the hydrogen urate over the concentration rang e 10(-2)-10(-5)M and pH 5-7. Many substances and ions cause no interfe rence. A standard addition method has been used for determination of u ric acid in serum, urine, and commercial standard uric acid and the re sults of determination were 3.0 to 7.2 mg%, 0.21 to 1.04 mg% and 4.5 X 10(-5) to 4.9 X 10(-3) mg%, respectively.