SPECTROPHOTOMETRIC DETERMINATION OF DICLOFENAC SODIUM IN GEL-OINTMENT

Authors
KRAMANCHEVA I DOBREV I BRAKALOV L
Citation
I. Kramancheva et al., SPECTROPHOTOMETRIC DETERMINATION OF DICLOFENAC SODIUM IN GEL-OINTMENT, Analytical letters, 30(12), 1997, pp. 2235-2249
Citations number
20
Categorie Soggetti
Chemistry Analytical
Journal title
Analytical letters → ACNP
ISSN journal
00032719
Volume
30
Issue
12
Year of publication
1997
Pages
2235 - 2249
Database
ISI
SICI code
0003-2719(1997)30:12<2235:SDODSI>2.0.ZU;2-H
Abstract
A direct spectrophotometric method has been developed for quantitative determination of Diclofenac Sodium in gel-ointments. The reported tec hnique does not require a separation step and it is based on only one extraction of Diclofenac Sodium from the gel-ointment and measurement of the absorbance at two wavelengths. This procedure allows also indir ect quantitative determination of degradation products due to indolino ne cyclization. The method is rapid, simple, specific, reproducible an d stability indicating.