EFFECT OF SMALL-SCALE CULTURE VESSEL TYPE ON HYPHAL FRAGMENT SIZE ANDERYTHROMYCIN PRODUCTION IN SACCHAROPOLYSPORA-ERYTHRAEA

Authors
BUSHELL ME DUNSTAN GL WILSON GC
Citation
Me. Bushell et al., EFFECT OF SMALL-SCALE CULTURE VESSEL TYPE ON HYPHAL FRAGMENT SIZE ANDERYTHROMYCIN PRODUCTION IN SACCHAROPOLYSPORA-ERYTHRAEA, Biotechnology letters, 19(9), 1997, pp. 849-852
Citations number
12
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Biotechnology letters → ACNP
ISSN journal
01415492
Volume
19
Issue
9
Year of publication
1997
Pages
849 - 852
Database
ISI
SICI code
0141-5492(1997)19:9<849:EOSCVT>2.0.ZU;2-1
Abstract
Erythromycin production dynamics in stirred, baffled shaken and non-ba ffled shaken flasks was strongly correlated with the different distrib utions of hyphal particle diameters observed. Production only took pla ce when hyphal fragments with diameters greater than 88 mu m were obse rved. Results are consistent with significant hyphal breakage rates, e ven in non-baffled shaken flasks.