LIPASE-CATALYZED ESTERIFICATION IN ORGANIC-SOLVENT TO RESOLVE RACEMICNAPROXEN

Authors
CUI YM WEI DZ YU JT
Citation
Ym. Cui et al., LIPASE-CATALYZED ESTERIFICATION IN ORGANIC-SOLVENT TO RESOLVE RACEMICNAPROXEN, Biotechnology letters, 19(9), 1997, pp. 865-868
Citations number
7
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Biotechnology letters → ACNP
ISSN journal
01415492
Volume
19
Issue
9
Year of publication
1997
Pages
865 - 868
Database
ISI
SICI code
0141-5492(1997)19:9<865:LEIOTR>2.0.ZU;2-4
Abstract
Lipase from Candida cylindracea was used to catalyze the enantioselect ive esterification in isooctane to resolve naproxen. The conversion wa s 33.5% over 11 days. The enantiomer excess of product (ee(p)%) was ab out 100% at this conversion when octanol acted as the other substrate.