TRANSESTERIFICATION OF ALKYLPHOSPHATE ESTERS BY PHOSPOLIPASE-D

Authors
AURICH I DURRSCHMIDT P HIRCHE F ULBRICHHOFMANN R
Citation
I. Aurich et al., TRANSESTERIFICATION OF ALKYLPHOSPHATE ESTERS BY PHOSPOLIPASE-D, Biotechnology letters, 19(9), 1997, pp. 875-879
Citations number
13
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Biotechnology letters → ACNP
ISSN journal
01415492
Volume
19
Issue
9
Year of publication
1997
Pages
875 - 879
Database
ISI
SICI code
0141-5492(1997)19:9<875:TOAEBP>2.0.ZU;2-P
Abstract
Phospholipase D from cabbage or Streptomyces chromofuscus catalyses th e transesterification of alkylphosphate esters, which are potent antit umor agents. The exchange of choline in octadecylphosphosphocholine by N-(2-hydroxyethyl)-N-methylpiperidine with phospholipase D from cabba ge is kinetically controlled and amounts to maximum 60% in buffer, 43% in buffer/n-hexane, and 82% in buffer/n-hexane/1-octanol.