TRANSFORMATION OF CHOLANIC ACID-DERIVATIVES INTO PHARMACOLOGICALLY ACTIVE ESTERS OF PHENOLIC-ACIDS BY HETEROGENEOUS WITTIG REACTION

Authors
IVANOVA A MILKOVA T GALABOV AS NIKOLAEVA L VOYNOVA E
Citation
A. Ivanova et al., TRANSFORMATION OF CHOLANIC ACID-DERIVATIVES INTO PHARMACOLOGICALLY ACTIVE ESTERS OF PHENOLIC-ACIDS BY HETEROGENEOUS WITTIG REACTION, Zeitschrift fur Naturforschung. C, A journal of biosciences, 52(7-8), 1997, pp. 516-521
Citations number
7
Categorie Soggetti
Biology
Journal title
Zeitschrift fur Naturforschung. C, A journal of biosciences → ACNP
ISSN journal
09395075
Volume
52
Issue
7-8
Year of publication
1997
Pages
516 - 521
Database
ISI
SICI code
0939-5075(1997)52:7-8<516:TOCAIP>2.0.ZU;2-0
Abstract
Steroid esters of cynnamic acid derivatives have been synthesized by a heterogeneous Wittig reaction under sonochemical conditions from the corresponding triphenylphosphonium bromides and unprotected phenolic a ldehyds using K2CO3 as a base. 5 beta-Cholan-3 alpha, 7 alpha, 12 alph a, 24-E-ferulate (11') exhibited a marked inhibitory effect on influen za virus A. The synthetic 3 alpha, 24-E-diferulates of 5 beta-cholan-3 alpha, 24-diol, 5 beta-cholan-3 alpha, 12 alpha, 24-triol and 5 beta- cholan-3 alpha, 7 alpha, 12 alpha, 24-tetrol (8, 9 and 12) showed anti tumor activity on leukemia P-388 in mice.