HEMODYNAMIC SIMULATIONS AND COMPUTER-AIDED DESIGNS OF GRAFT-ARTERY JUNCTIONS

Severe occlusion of graft-artery junctions due to restenosis, e.g., ex cessive tissue overgrowth and renewed plaque formation, may occur with in a few months or years after bypass surgery. Our hypothesis is that nonuniform hemodynamics, represented by large sustained wall shear str ess gradients, trigger-abnormal biological processes leading to rapid restenosis and hence early graft failure. In turn, this problem may be significantly mitigated by designing graft-artery bypass configuratio ns for which the wall shear stress gradient (WSSG) is approximately ze ro and hence nearly uniform hemodynamics are achieved focusing on the distal end of several femoral artery bypass junctions, a validated fin ite volume code has been used to compute the transient three-dimension al velocity vector fields and its first and second surface derivatives in order to test the idea. Specifically, it is shown that the Taylor patch, which generates higher patency rates than standard end-to-side anastomoses, exhibits lower WSSG levels than standard configurations, and that further geometric design improvements reduce the WSSG in magn itude and local extent even more.