SPECTROPHOTOMETRIC DETERMINATION OF OFLOXACIN AND LOMEFLOXACIN HYDROCHLORIDE WITH SOME SULPHONPHTHALEIN DYES

Three spectrophotometric methods for the determination of ofloxacin an d lomefloxacin hydrochloride are proposed which are based on their ext raction into chloroform as ion pairs with Bromophenol Blue (BPB), Brom othymol Blue (BTB) and Bromocresol Purple (BCP). The calibration graph s generated were linear over the range 5-25, 2-15 and 2-20 mu g ml(-1) of drug in chloroform, using three dyes, respectively. The compositio n of the ion pair was established by continuous variation and molar ra tio methods. The described methods were utilized for assaying ofloxaci n and lomefloxacin hydrochloride in pharmaceutical preparations.