Severe congenital deficiency of factor X was diagnosed in a 3-year-old
castrated male domestic shorthair cat with clinical signs of generali
zed seizures and prolonged bleeding after venipuncture. Heritability o
f factor X deficiency was suspected because of a prolonged Russell's v
iper venom time in the dam and reductions in factor X activity in the
dam and 1 sibling. To our knowledge, factor X deficiency in cats has n
ot been reported previously. Definitive diagnosis for animals with cli
nical signs of coagulopathy may require repetition of coagulation scre
ening tests using different assay methods or specific coagulation fact
or analyses.