M. Barbato et al., EFFECTS OF TIMING OF CONCEPTION ON BIRTH-WEIGHT AND PRETERM DELIVERY OF NATURAL FAMILY-PLANNING USERS, Advances in contraception, 13(2-3), 1997, pp. 215-228
Objective: Various birth defects and untoward perinatal outcomes have
been claimed to be associated with pregnancies conceived by gametes ag
ed in vivo before fertilization. Thus, these outcomes were systematica
lly assessed in pregnancies occurring in natural family planning (NFP)
users. Our international multicenter cohort study of NFP pregnancies
(n = 877) is by far the largest systematic study designed to assess pr
egnancy outcome and is of sufficient power to allow us to address the
concern of low birth weight (< 2500 g) and preterm delivery (< 37 week
s gestation). Study design: In addition to gathering baseline medical
data, evaluation was performed at 16 weeks, 32 weeks and at term. Data
were collected in a systematic cohort fashion, verified by the five c
ollaborating international recruiting centers, and analyzed by investi
gators in the US. Most recruiting center principal investigators are o
bstetrician-gynecologists and, if not, have integral relationships wit
h such specialists. Standard criteria could thus be applied within and
among centers. In our cohort, birth weight was recorded accurately at
delivery. Almost all of the deliveries occurred in hospitals; thus, d
ata should be quite reliable. Neonatal examination for anomalies was u
sually conducted immediately after delivery, when birth weight was rec
orded. Results: Analysis of risk factors for low birth weight and pret
erm delivery showed that this population had a low risk profile. Low b
irth weight infants (< 2500 g) and preterm deliveries were increased a
mong women with a history of either prior low birth weight or preeclam
psia in the index pregnancy. However, mean birth weight was unaffected
by the timing of conception vis a vis ovulation or pregnancy history.
Mean birth weight for the 877 singleton NFP pregnancies was 3349.6 g.
The risk of preterm delivery was increased among older women who dran
k alcohol, but there were no significant effects of timing of concepti
on vis a vis ovulation on preterm delivery. Results held when analysis
was stratified according to whether NFP was being used for contracept
ion or to achieve pregnancy. Conclusions: Our data do not appear to sh
ow striking differences between 877 NFP pregnancies and the general ob
stetric population. The timing of conception vis a vis ovulation does
not exert significant effects on the birth weight or preterm delivery
of resulting pregnancies, a reassuring finding for NFP users.