ORGANOMETALLIC COMPLEXES WITH BIOLOGICAL MOLECULES .9. O-TIN(IV)[MESO-TETRA(4-SULFONATOPHENYL)PORPHINATE] AND O-TIN(IV)[MESO-TETRA(4-SULFONATOPHENYL)PORPHINATE] DERIVATIVES - SOLID-STATE AND SOLUTION-PHASE STRUCTURAL ASPECTS AND IN-VIVO EFFECTS

Diorgano-and triorgano-tin(IV) derivatives of meso-tetra(4-sulfonatoph enyl)porphine (H4TPPS) with general formula (R2Sn)(2)TPPS and (R3Sn)(4 )TPPS (TPPS4- = [meso-tetra(4-sulfonatophenyl)porphinate](4-), R = Me, Bu, Ph) have been obtained and their solid-state configuration inferr ed on the basis of IR and Mossbauer spectroscopy, while solution-phase studies have been carried out by H-1 and C-13 NMR in DMSO-d(6), toget her with determination of the in vivo cytotoxicity of the new derivati ves towards embryonic development of Ciona intestinalis. In particular , octahedral and trigonal-bipyramidal eq-R3Sn polymeric configurations are proposed, in the solid state, respectively for (R2Sn)(2)TPPS and (R3Sn)(4)TPPS complexes, with the arylsulfonate groups behaving as mon oanionic bidentate bridging ligands. The H-1 and C-13 NMR data lead to the conclusion that the metal-to-ligand ratio (2:1 or 4:1), binding s ite (the sulfonato-group oxygens), and the coordination polyhedron aro und the metal (trans-octahedral or trigonal-bipyramidal) found in the solid state are preserved in solution. (C) 1997 by John Wiley & Sons, Ltd.