SYNTHESIS, CHARACTERISTIC SPECTRAL STUDIES AND IN-VITRO ANTIMICROBIALAND ANTITUMOR ACTIVITIES OF ORGANOTIN(IV) COMPLEXES OF SCHIFF-BASES DERIVED FROM AMINO-ACIDS

Equimolar reactions of dibutyltin(IV) oxide with Schiff bases derived from amino-acids led to the formation of a new series of dibutyltin(IV ) complexes of general formula, Bu2SnL [L = dianion of tridentate Schi ff bases derived from the condensation of 2-hydroxy-1-naphthaldehyde o r acetyl acetone with glycine (L-l), L-beta-alanine (L-2), DL-valine ( L-3), DL-4-aminobutyric acid (L-4), L-methionine (L-5), L-leucine (L-6 ) and phenylglycine (L-7)]. An attempt has been made to prove the stru ctures of the resulting complexes on the basis of elemental analyses, conductance measurements and electronic, IR, multinuclear magnetic res onance (H-1, C-13 and Sn-117) and Sn-119 Mossbauer spectral studies. T he complexes have been tested against various bacteria [streptococcus faecalis, Klebsiella pneumoniae, Escherichia coil, Pseudomonas aerugin osa, Staphylococcus aureus penicillin resistance (2500 units)] and fun gi (Candida albicans, Cryptococcus neoformans, Sporotrichum schenckii, Trichophyton mentagrophytes and Aspergillus fumigatus). All the compl exes showed moderate activity. The cytotoxicity of a few compounds has been screened in vitro against seven human tumour cell lines, viz. MC F-7, EVSA-T, WiDr, IGROV, M19 MEL, A498 and H226. The activities found experimentally were better than those obtained for cisplatin and carb oplatin. (C) 1997 by John Wiley & Sons, Ltd.