Purpose. Ablating and cutting vitreoretinal membranes using a 193-nm e
xcimer laser-based microsurgical system. Methods. A 193-nm microsurgic
al system enables delivery of the beam into a fluid medium to cut prer
etinal and subretinal membranes. Two patients with proliferative diabe
tic retinopathy and one patient with proliferative vitreoretinopathy w
ere treated with this new device. Results. Gentle ablation and cutting
of the preretinal and subretinal membranes without exerting any tract
ion on or apparent damage to the neighboring tissue was achieved. Conc
lusions. The technology is applicable to a variety of intraocular vitr
eoretinal surgical procedures.