EPI-INOSITOL IS BIOCHEMICALLY ACTIVE IN REVERSING LITHIUM EFFECTS ON CYTIDINE MONOPHOSPHORYLPHOSPHATIDATE (CMP-PA)

Authors
RICHARDS MH BELMAKER RH
Citation
Mh. Richards et Rh. Belmaker, EPI-INOSITOL IS BIOCHEMICALLY ACTIVE IN REVERSING LITHIUM EFFECTS ON CYTIDINE MONOPHOSPHORYLPHOSPHATIDATE (CMP-PA), Journal of neural transmission, 103(11), 1996, pp. 1281-1285
Citations number
15
Categorie Soggetti
Clinical Neurology",Neurosciences
Journal title
Journal of neural transmission → ACNP
ISSN journal
03009564
Volume
103
Issue
11
Year of publication
1996
Pages
1281 - 1285
Database
ISI
SICI code
0300-9564(1996)103:11<1281:EIBAIR>2.0.ZU;2-P
Abstract
In CHOm(3) cells and rat cerebral cortex slices, epi-inositol was less potent but as effective as myo-inositol in reversing carbachol/lithiu m-stimulated CMP-PA accumulation whereas L-chiro-and scyllo-inositol w ere less active or inactive. These results with the four inositol isom ers in two tissues correlate exactly with their effects on lithium-pil ocarpine induced seizures and suggest a common mechanism of action for biochemical and behavioural effects.