PET STUDY OF COMPETITION BETWEEN INTRAVENOUS COCAINE AND [C-11] RACLOPRIDE AT DOPAMINE-RECEPTORS IN HUMAN-SUBJECTS

Objective: Animal data suggest that the strong euphoriant effects of c ocaine are related to the drug's enhancement of available dopamine at the synaptic cleft. The authors' goal was to determine whether this me chanism is the same in humans because the development of putative phar macological agents for treatment of cocaine dependence depends on this knowledge. Method: Positron emission tomography with [C-11]raclopride was used to examine she effects of the intravenous administration of 48mg of cocaine (a typical ''street'' dose) on the occupancy of dopami ne 2 receptors in the putamen of 11 self-identified intravenous drug a busers. Results: All 11 subjects reported subjective stimulation and e uphoria in reponse to cocaine nt the receptor site. Conclusions: These results support the concept of dopamine system involvement in human c ocaine abuse.