2 CASES OF ROBERTSONIAN TRANSLOCATIONS IN OLIGOZOOSPERMIC MALES AND THEIR CONSEQUENCES FOR PREGNANCIES INDUCED BY INTRACYTOPLASMIC SPERM INJECTION

Two case histories are presented documenting structural chromosome abn ormalities in infertile males, The abnormalities were detected only af ter application of intracytoplasmic sperm injection (ICSI) was repeate dly unsuccessful or resulted in an abnormal pregnancy, A mosaic Robert sonian translocation 45,XY,der(13;13)(q10;q10)/46,XY,t(13;13)(p10;p10) , der(13p;13p) incompatible with normal offspring was found in a male with extreme oligozoospermia after three subsequent ICSI treatments we re unsuccessful and one had resulted in a spontaneous abortion, A seco nd case involved a Robertsonian translocation 45,XY,der(13;14)(q10;q10 ) which was detected in a male with extreme oligozoospermia after ultr asound abnormalities were found in an ICSI-induced twin pregnancy, Amn iocentesis showed an unbalanced 46,XY,+13,der(13;13)(q10;q10) karyotyp e in one twin and a Robertsonian 45,XX,der(13;14)(q10;q10) karyotype i n the other twin. Chromosome analysis of males with abnormal sperm cha racteristics is advised prior to ICSI.