P. Vercellini et al., THE ROLE OF TRANSVAGINAL ULTRASONOGRAPHY AND OUTPATIENT DIAGNOSTIC HYSTEROSCOPY IN THE EVALUATION OF PATIENTS WITH MENORRHAGIA, Human reproduction, 12(8), 1997, pp. 1768-1771
To verify the reliability of transvaginal ultrasonography in diagnosin
g intrauterine disease and in evaluating the operability of submucous
myomas and to determine the feasibility, acceptability and validity of
hysteroscopy for menorrhagia, we performed a prospective 5 year study
on 793 women of mean age +/- SD of 41.5 +/- 7.8 years, All the patien
ts referred for excessive menstrual bleeding with uterine volume (12 w
eek pregnancy who underwent complete physical examination, transvagina
l ultrasonography and outpatient hysteroscopy with endometrial biopsy
were included in the study, Outpatient hysteroscopy was not completed
due to intolerance or was unsatisfactory due to excessive bleeding in
23 cases (2.9%), Only 28 women (3.5%) declared they mould have refused
the procedure had they imagined the pain involved, One case of pelvic
infection was observed, Compared with hysteroscopy, transvaginal ultr
asonography had 96% sensitivity, 86% specificity, 91% positive predict
ive value and 94% negative predictive value in the diagnosis of intrau
terine abnormality, The sensitivity, specificity, positive and negativ
e predictive values of ultrasonography in identifying submucous myomas
operable hysteroscopically (intramural extension <50%) were respectiv
ely 80, 69, 83 and 65% with a k index of agreement between ultrasonogr
aphy and hysteroscopy of 0.48, Thus, considering the good specificity
and high negative predictive value, transvaginal ultrasonography may b
e suggested as the initial investigation in menorrhagic patients, limi
ting hysteroscopy to cases with positive or doubtful sonographic findi
ngs.