SYNTHESIS AND ANTICANDIDAL ACTIVITIES OF OPTIMIZED ANALOGS OF ANTIBIOTIC SCH-37137

Authors
ANDRUSZKIEWICZ R ZIENIAWA T CHMARA H KASPRZAK L BOROWSKI E
Citation
R. Andruszkiewicz et al., SYNTHESIS AND ANTICANDIDAL ACTIVITIES OF OPTIMIZED ANALOGS OF ANTIBIOTIC SCH-37137, Journal of antibiotics, 47(6), 1994, pp. 715-723
Citations number
23
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
47
Issue
6
Year of publication
1994
Pages
715 - 723
Database
ISI
SICI code
0021-8820(1994)47:6<715:SAAAOO>2.0.ZU;2-Z
Abstract
Peptide analogues of Sch 37137 the antifungal antibiotic have been syn thesized and evaluated in vitro against Candida sp. Di- and tripeptide s containing methionine, leucine, norvaline, lysine, glutamic acid and -3-(trans-epoxysuccinamoyl)-L-2,3-diaminopropanoic acid, (EADP) were obtained. Peptides containing (D)-, and (L)-trans-epoxysuccinamic acid were also prepared. All of the analogues examined displayed in genera l higher anticandidal activity than a mixture of. diastereomers of Sch 37137.