POSTOPERATIVE ENTERITIS CAUSED BY METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS

We examined the clinical features of 14 men (mean age 72 years) with p ostoperative enteritis caused by methicillin-resistant Staphylococcus aureus (MRSA). The patients had all undergone surgery for the treatmen t of digestive diseases and had received antibiotic prophylaxis consis ting of an extended-spectrum cephem, Diarrhea appeared a mean of 3.3 d ays postoperatively and lasted for 5 days on average. In severe cases organ insufficiency nas involved. Coagulase-positive staphylococci wer e the predominant organisms isolated from watery diarrhea, In 13 of 14 patients, coagulase type II isolates producing enterotoxins A, C and toxic shock syndrome toxin-1 (TSST-1) with enterotoxin A, C, and tst g enes were isolated, These strains were sensitive to vancomycin and arb ekacin; however, they were highly resistant to many other antibiotics, We also investigated the effects of a glucocorticoid hormone and gamm a globulin on production of tumor necrosis factor-alpha (TNF-alpha) an d interleukin -2 (IL-2) obtained from healthy volunteers, TNF-alpha an d IL-2 production was enhanced by TSST-1 and the supernatant of Iscove modified dulbecco medium, in which coagulase type II isolates produci ng enterotoxins A, C and TSST-1 with enterotoxin A, C were cultured fo r 24 h. Both glucocorticoid hormone and gamma globulin suppressed TNF- alpha and IL-2 production, thus suggesting that these drugs may be eff ective in treating postoperative MRSA enteritis.