FOLLOW-UP OF 2 CASES OF PAPILLON-LEFEVRE SYNDROME AND PRESENTATION OF2 NEW CASES

Periodontitis resulting from Papillon-Lefevre Syndrome has been known to cause early loss of primary dentition with subsequent involvement o f the permanent dentition. In this study two Papillon-Lefevre Syndrome patients were followed for 3 years offer initial treatment and improv ement of their periodontal condition. In addition two new cases of Pap illon-Lefevre Syndrome are presented. The follow-up treatment of the f irst two patients included monitoring the oral hygiene and performing ultrasonic scaling. Their present clinical appearance is very satisfac tory The periodontal condition of the third (new) patient was brought under control by extracting the involved deciduous teeth under antibio tic coverage, and by scaling and roof planing the already erupted perm anent teeth as well as by maintaining a high standard of oral hygiene. In the fourth case, all permanent teeth had erupted and the periodont ium had already been severely destroyed. Actinobacillus actinomycetemc omitans was not defected by microbiologic examination offer the period ontal conditions improved, except in the fourth case. Western blot ana lysis showed that the three first three patients had positive antibody response to the same antigens of Actinobacillus actinomycetemcomitans . Phagocytosis by polymorphonuclear neutrophil leukocytes) had not dec reased, but the expression of surface receptors of polymorphonuclear n eutrophil leukocytes was within the normal limits.