Successful vaccination and removal programs have greatly reduced the i
ncidence of feline leukemia virus (FeLV) in the United States pet cat
population over the last decade. Still, a significant proportion of fr
ee-roaming pet and feral cats remain chronically infected with the vir
us. A mathematical model was created to explore previously published d
ynamics of this virus against a set of purpose-designed differential e
quations in a ''virtual world'' in which the effects of vaccination an
d test and removal programs on the prevalence of FeLV in selected subp
opulations of domestic cats could be studied. The results of the hypot
heses are reported and discussed.