THE SOLUTION STRUCTURE OF THE FIRST KH DOMAIN OF FMR1, THE PROTEIN RESPONSIBLE FOR THE FRAGILE-X-SYNDROME

Authors
MUSCO G KHARRAT A STIER G FRATERNALI F GIBSON TJ NILGES M PASTORE A
Citation
G. Musco et al., THE SOLUTION STRUCTURE OF THE FIRST KH DOMAIN OF FMR1, THE PROTEIN RESPONSIBLE FOR THE FRAGILE-X-SYNDROME, Nature structural biology, 4(9), 1997, pp. 712-716
Citations number
34
Categorie Soggetti
Biology,"Cell Biology
Journal title
Nature structural biology → ACNP
ISSN journal
10728368
Volume
4
Issue
9
Year of publication
1997
Pages
712 - 716
Database
ISI
SICI code
1072-8368(1997)4:9<712:TSSOTF>2.0.ZU;2-6
Abstract
The structure and dynamics of the first KH domain of FMR1 - the protei n responsible for fragile X syndrome - reveal that an exposed loop is highly flexible despite containing a GxxG motif that is well conserved throughout the KH family. We suggest that this region provides a puta tive binding surface for RNA recognition.