THE KEY MUST FIT - MACROPHAGES TRANSPORT PRION INFECTION TO THE CENTRAL-NERVOUS-SYSTEM AND MAY DETERMINE THE SITES OF INFECTION WITHIN IT

Authors
DEALLER S
Citation
S. Dealler, THE KEY MUST FIT - MACROPHAGES TRANSPORT PRION INFECTION TO THE CENTRAL-NERVOUS-SYSTEM AND MAY DETERMINE THE SITES OF INFECTION WITHIN IT, Medical hypotheses, 49(3), 1997, pp. 213-220
Citations number
68
Categorie Soggetti
Medicine, Research & Experimental
Journal title
Medical hypotheses → ACNP
ISSN journal
03069877
Volume
49
Issue
3
Year of publication
1997
Pages
213 - 220
Database
ISI
SICI code
0306-9877(1997)49:3<213:TKMF-M>2.0.ZU;2-Y
Abstract
It is suggested that the agent for transmissible spongiform encephalop athies is trasferred from an original peripheral site of infection int o the brain by recruited and selected circulating macrophages/monocyte s. It is because of this selection that strains of disease appear to b e different when infecting separate species, but retain characteristic s when infecting a single species.