MAPPING OF A FAMILIAL ESSENTIAL TREMOR GENE, FET1, TO CHROMOSOME 3Q13

Citation
Jr. Gulcher et al., MAPPING OF A FAMILIAL ESSENTIAL TREMOR GENE, FET1, TO CHROMOSOME 3Q13, Nature genetics, 17(1), 1997, pp. 84-87
Citations number
30
Categorie Soggetti
Genetics & Heredity
Journal title
ISSN journal
10614036
Volume
17
Issue
1
Year of publication
1997
Pages
84 - 87
Database
ISI
SICI code
1061-4036(1997)17:1<84:MOAFET>2.0.ZU;2-0
Abstract
Essential tremor (ET), the most common movement disorder in humans, ap pears to be inherited as an autosomal dominant trait in many families( 1,2). The familial form is called familial essential tremor (FET), whi ch seems similar to sporadic essential tremor. ET is a cause of substa ntial disability, particularly in the elderly(1). The prevalence of Pa rkinson's disease and dystonia may be increased in families with ET, b ut other movement disorders are seldom encountered in these families(3 ,4). Here we report the results of a genome-wide scan for FET genes in 16 Icelandic families with 75 affected individuals, in whom FET was a pparently inherited as a dominant trait. The scan, which was performed with a 10-cM framework map, revealed one locus on chromosome 3q13 to which FET mapped with a genome-wide significance when the data were an alysed either parametrically, assuming an autosomal dominant model (Io d score = 3.71), or non-parametrically (NPL Z score = 4.70. P < 6.4 x 10(6)).