THE SYNTHESIS OF THIENOPYRIDINES FROM ORTHO-HALOGENATED PYRIDINE-DERIVATIVES .2.

Synthetic routes to rhs ortho-halogenated pyridine derivatives, ethyl 2- and 4-chloro-3-pyridylacetate, ethyl 3-bromo-4-pyridylacetate and e thyl 3-bromo-2-pyridylacetate, which have methylene groups activated b y the ester functionality are reported. Reaction of these pyridines wi th carbon disulfide in the presence of sodium hydride, followed by que nching with iodomethane, results in the formation of the corresponding thienopyridines in moderate yields.