[TRANS-EN(2)OS(ETA-H-2)](2-1-NMR PROBE FOR THE COORDINATION OF SOME ANTICANCER METAL-COMPLEXES TO DEOXYGUANOTIDE() AS AN H)

Authors
YANG P GUO ML LI QS TIAN YN LI ZW TAUBE H
Citation
P. Yang et al., [TRANS-EN(2)OS(ETA-H-2)](2-1-NMR PROBE FOR THE COORDINATION OF SOME ANTICANCER METAL-COMPLEXES TO DEOXYGUANOTIDE() AS AN H), Science in China. Series B, Chemistry, life sciences & earth sciences, 40(5), 1997, pp. 541-547
Citations number
15
Categorie Soggetti
Chemistry
Journal title
Science in China. Series B, Chemistry, life sciences & earth sciences → ACNP
ISSN journal
1001652X
Volume
40
Issue
5
Year of publication
1997
Pages
541 - 547
Database
ISI
SICI code
1001-652X(1997)40:5<541:[PFTCO>2.0.ZU;2-F
Abstract
The molecular hydrogen complex of osmium, [trans-en(2)Os(eta-H-2)](2+) (en, entlylendediamine) is a new H-1 NMR recognition probe for biomole cules. By using this probe, the coordination between deoxyguanylic aci d (dGMP) and four metal anticancer complexes, titanocene dichloride, ( C2H5)(2)SnCl2(phen), (C2H5)(2)SnCl2 and cisplatin are studied in D2O u nder the condition near the physiological one. The results show that t he former three complexes mainly and strongly coordinate with the phos phate oxygen of dGMP, while cisplatin mainly coordinates with N(7) of dGMP.