Dj. Kereiakes et al., PARTIAL REVERSAL OF HEPARIN ANTICOAGULATION BY INTRAVENOUS PROTAMINE IN ABCIXIMAB-TREATED PATIENTS UNDERGOING PERCUTANEOUS INTERVENTION, The American journal of cardiology, 80(5), 1997, pp. 633
Serious hemorrhage and vascular complications after abciximab therapy
are associated with elevated activated clotting time values. Our preli
minary experience suggests that low-dose intravenous protamine adminis
tration is both safe and effective in reducing elevated in-laboratory
activated clotting time values and the potential for serious hemorrhag
e in abciximab-treated patients.