F. Ichida et al., ADDITIVE EFFECT OF BERAPROST ON PULMONARY VASODILATION BY INHALED NITRIC-OXIDE IN CHILDREN WITH PULMONARY-HYPERTENSION, The American journal of cardiology, 80(5), 1997, pp. 662
Combined administration of inhaled nitric oxide and beraprost sodium r
esulted in a more intense decrease in pulmonary vascular resistance th
an nitric oxide given alone (mean -33% vs -45%, p < 0.05), without ser
ious systemic hypotension. Combined therapy with nitric oxide and bera
prost sodium is highly desireable in treating primary and secondary pu
lmonary hypertension in children.