I-KAPPA-B PROTEINS - STRUCTURE, FUNCTION AND REGULATION

The Rel/NF-kappa B transcription factors represent the paradigm? of re gulation of transcriptional activation through subcellular localizatio n. In unstimulated cells, NF-kappa B exists in an inactive state in th e cytoplasm complexed to the inhibitory I kappa B molecules. Upon stim ulation, I kappa B is rapidly degraded, freeing NF-kappa B to transloc ate to the nucleus and to activate the expression, of its target genes . In this chapter, we will summarize what is known about the structure of I kappa B molecules, their functions, the mechanisms of I kappa B degradation, and the most common upstream signaling pathway (that is, serine phosphorylation) that leads to I kappa B degradation. Finally, we will discuss alternative mechanisms for induction of NF-kappa B thr ough regulation of I kappa B activity. (C) 1997 Academic Press Ltd.