SYNTHESIS AND ANTIFUNGAL ACTIVITY OF N-SU BSTITUTED-ALPHA-OXOCYCLODODECYLSULPHONAMIDES

A series of N-substituted-alpha-oxocyclododecylsulphonamides (III) hav e been synthesized by amination of alpha-oxocyclododecylsulphonic acid chloride, obtained from the readily available cyclododecanone via alp ha-oxocyclododecylsulphonic acid. Their structures were confirmed by I R, MS, H-1 NMR and elementary analysis. The bioassay for antifungal ac tivity was carried out and all the title compounds were found to be ac tive against Gibberella zeae. The compounds showing the highest activi ty are those substituted by a chlorophenyl group on the nitrogen atom (III 8, III 7). Their structure-activity relationship was discussed by means of conformational analysis.