(S)-UH301, A SILENT 5-HT(1A) RECEPTOR ANTAGONIST, ENHANCES PLASMA-CORTICOSTERONE LEVELS IN THE RAT

Authors
GROENINK L VANDERGUGTEN J MOS J MAES RAA OLIVIER B
Citation
L. Groenink et al., (S)-UH301, A SILENT 5-HT(1A) RECEPTOR ANTAGONIST, ENHANCES PLASMA-CORTICOSTERONE LEVELS IN THE RAT, Life sciences, 55(5), 1994, pp. 99-103
Citations number
11
Categorie Soggetti
Biology,"Medicine, Research & Experimental","Pharmacology & Pharmacy
Journal title
Life sciences → ACNP
ISSN journal
00243205
Volume
55
Issue
5
Year of publication
1994
Pages
99 - 103
Database
ISI
SICI code
0024-3205(1994)55:5<99:(AS5RA>2.0.ZU;2-8
Abstract
The putative silent 5-HT1A receptor antagonist (S)-UH301 S-5-fluoro-8- hydroxy-2-(di-n-propylamino)tetralin) dose-dependently enhanced (3 to 10 mg/kg, sc) plasma corticosterone levels in undisturbed rats, an eff ect shared with 5-HT1A receptor agonists. (S)-UH301 did not influence plasma glucose levels. This unexpected finding may be indicative of a partial 5-HT1A-receptor agonistic effect of (S)-UH301, or reveals a hi therto unknown mechanism of action in (S)-UH301.