EFFECT OF HEPARIN ON INFECTION OF CELLS BY EQUINE ARTERITIS VIRUS

The number of plaques formed by equine arteritis virus (EAV) and Aujes ky's disease virus (ADV) was reduced to 14% and 5% of the untreated co ntrol(100%), respectively, by 10 U/ml of heparin, but could not be red uced below to 13 and 4%, respectively, by use of concentration up to 1 00 U/ml. An inhibitory effect of heparin, at concentration up to i00 U /ml, was nor observed on parainfluenza virus 3 (PIV-3). Heparinase tre atment of RK13 cells reduced the number of EAV-, as well as ADV-induce d plaques. On the other hand, the number of PIV-3 induced plaques did not decrease after treatment of RK13 cells with heparinase.