ENDOTOXIN-INDUCED LETHALITY IN NEONATAL MICE IS COUNTERACTED BY INTERLEUKIN-10 (IL-10) AND EXACERBATED BY ANTI-IL-10

Authors
NICOLETTI F MANCUSO G CILIBERTI FA BENINATI C CARBONE M FRANCO S CUSUMANO V
Citation
F. Nicoletti et al., ENDOTOXIN-INDUCED LETHALITY IN NEONATAL MICE IS COUNTERACTED BY INTERLEUKIN-10 (IL-10) AND EXACERBATED BY ANTI-IL-10, Clinical and diagnostic laboratory immunology, 4(5), 1997, pp. 607-610
Citations number
23
Categorie Soggetti
Immunology,"Infectious Diseases","Medical Laboratory Technology",Microbiology
Journal title
Clinical and diagnostic laboratory immunology → ACNP
ISSN journal
1071412X
Volume
4
Issue
5
Year of publication
1997
Pages
607 - 610
Database
ISI
SICI code
1071-412X(1997)4:5<607:ELINMI>2.0.ZU;2-X
Abstract
The lethal effects occurring in neonatal (<24-h-old) BALB/c mice after challenge with 25 mg of lipopolysaccharide (LPS) per kg of body weigh t were significantly counteracted by pretreatment with recombinant int erleukin-10 (rIL-10; 25 or 50 ng/mouse). Concordantly, blockage of end ogenous IL-10 with the SXC1 monoclonal antibody increased LPS-induced mortality. Both IL-10 and SXC1 modulated the release of tumor necrosis factor alpha (TNF-alpha) so that, relative to controls, peak TNF-alph a values after LPS challenge were decreased by rIL-10 and increased by anti-IL-10.