A NEWLY RECOGNIZED CAUSE OF WHEEZING - AIDS-RELATED BRONCHIAL LEIOMYOMAS

We present two human immunodeficiency virus-infected children who deve loped wheezing and radiological evidence of pulmonary air trapping due to intra- and peribronchial leiomyomas. At autopsy, leiomyomas were a lso found in their spleens, which to our knowledge, has never been rep orted. The smooth muscle tumors were strongly positive for the Epstein -Barr virus, as demonstrated by in situ hybridization to Epstein-Barr virus-encoded ribonucleic acid, confirming the findings of recent inve stigators and linking these tumors to the Epstein-Barr virus. (C) 1997 Wiley-Liss, Inc.