Brain tumoral microembolism is a very unusual etiology of cerebral vas
cular disease in patients with cancer. The clinical course is characte
rized by diffuse encefalopathy with associated neurologic deficits. We
report a 72-year-old male patient, who developed rapidly progressive
dementia associated with diffuse myoclonic jerks, without neurologic d
eficit, whose brain biopsy showed microscopic emboli of adenocarcinoma
of unknown origin in capillary vessels. We did not find metastasis in
other organs. We suggest that this entity should be included in the d
ifferential diagnoses of the subacute dementias.