SYNTHESES IN SUPERHEATED AQUEOUS-MEDIA - PREPARATION OF FULLY DEUTERATED PYRAZOLES AND QUINOXALINES

Authors
JUNK T CATALLO WJ ELGUERO J
Citation
T. Junk et al., SYNTHESES IN SUPERHEATED AQUEOUS-MEDIA - PREPARATION OF FULLY DEUTERATED PYRAZOLES AND QUINOXALINES, Tetrahedron letters, 38(36), 1997, pp. 6309-6312
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
36
Year of publication
1997
Pages
6309 - 6312
Database
ISI
SICI code
0040-4039(1997)38:36<6309:SISA-P>2.0.ZU;2-M
Abstract
A general, post-synthetic labeling method for the preparation of fully deuterated pyrazoles and quinoxalines by base-induced isotope exchang e in superheated deuterium oxide is described. Examples include the sy nthesis of 2-methylquinoxaline-d(8), 2,3-dimethylquinoxaline-d(10), 3, 5-dimethylpyrazole-d(8), and 3,5-diphenylpyrazole-d(12). (C) 1997 Publ ished by Elsevier Science Ltd.