DEPRESSION-LIKE SYNDROME IN RATS INDUCED BY NEUROTOXIN MPTP AND AUTOANTIBODIES TO SEROTONIN AND DOPAMINE

Citation
La. Vetrile et al., DEPRESSION-LIKE SYNDROME IN RATS INDUCED BY NEUROTOXIN MPTP AND AUTOANTIBODIES TO SEROTONIN AND DOPAMINE, Zurnal vyssej nervnoj deatelnosti im. I.P. Pavlova, 47(4), 1997, pp. 731-739
Citations number
24
Categorie Soggetti
Physiology,Neurosciences
ISSN journal
00444677
Volume
47
Issue
4
Year of publication
1997
Pages
731 - 739
Database
ISI
SICI code
0044-4677(1997)47:4<731:DSIRIB>2.0.ZU;2-S
Abstract
Induction of autoantibodies to serotonin and dopamine in blood serum w as demonstrated in a new rat model of experimental depression-like syn drome induced by intraperitoneal injection of neurotoxin 1-methyl-4-ph enyl-1,2,3,6-tetrahydropyridine (MPTP, 20 mg/kg daily for 12 days), Th e level and frequency of detection of antibodies to serotonin within 2 and 3 weeks after MPTP withdrawal did not differ, and the level and f requency of detection of antibodies to dopamine were significantly red uced within 3 weeks as compared with 2 weeks after the MPTP withdrawal . In is suggested that disturbances in neuroimmune interactions play a n important part in development of depressive states.