La. Vetrile et al., DEPRESSION-LIKE SYNDROME IN RATS INDUCED BY NEUROTOXIN MPTP AND AUTOANTIBODIES TO SEROTONIN AND DOPAMINE, Zurnal vyssej nervnoj deatelnosti im. I.P. Pavlova, 47(4), 1997, pp. 731-739
Induction of autoantibodies to serotonin and dopamine in blood serum w
as demonstrated in a new rat model of experimental depression-like syn
drome induced by intraperitoneal injection of neurotoxin 1-methyl-4-ph
enyl-1,2,3,6-tetrahydropyridine (MPTP, 20 mg/kg daily for 12 days), Th
e level and frequency of detection of antibodies to serotonin within 2
and 3 weeks after MPTP withdrawal did not differ, and the level and f
requency of detection of antibodies to dopamine were significantly red
uced within 3 weeks as compared with 2 weeks after the MPTP withdrawal
. In is suggested that disturbances in neuroimmune interactions play a
n important part in development of depressive states.